Much of AI is predict - predict - predict

  • using ECG, predict presence of structural heart disease, typically diagnosed with cardiac echo
  • predict 10-year heart attack risk using basic medical information

The goal is impact on healthcare

ECG to SHD [@yaoArtificialIntelligenceEnabled2021]

  • prediction: structural heart disease
  • intervention: refer patient for cardiac echo
  • outcome: diagnosis of structural heart disease
  • outcome (impact): reduce preventable early cardiac death

10 year heart attack risk [@hippisley-coxDevelopmentValidationNew2024]

  • prediction: heart attack in 10 years
  • intervention: prescribe cholesterol lowering medication
  • outcome: heart attack
  • outcome (impact): reduce heart attacks

Process

  • data scientists optimize for predictive accuracy, which entails modeling statistical associations in the ‘healthcare system’
  • the hope is: better prediction \(\imply\) better impact
  • unfortunately, this is not automatically the case

When accurate prediction models yield harmful self-fulfilling prophecies [@vanamsterdamWhenAccuratePrediction2025]